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human protein atlas single-cell database  (Human Protein Atlas)

 
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    Human Protein Atlas human protein atlas single-cell database
    Human Protein Atlas Single Cell Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+protein+atlas+single-cell+database/human+protein+atlas+cell+atlas+database/pm40349158-56-45-42
    Average 90 stars, based on 1 article reviews
    human protein atlas single-cell database - by Bioz Stars, 2026-09
    90/100 stars

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    Expressing:

    Article Title: Inhibition of RACK1-Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome.
    Article Snippet: To figure out the expression profile of the NLRP3 inflammasome in ARDS, we commenced by analyzing single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) of thirteen ARDS patients and six healthy donors, as reported by Sawitzki et al. [24] The Human Protein Atlas single-cell database showed that NLRP3 was primarily expressed in myeloid cells (Figure S2A, Supporting Information).

    Article Title: Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure
    Article Snippet: The distribution of Kmt5a transcript expression in cardiac tissue, categorized into fibroblasts, endothelial cells, smooth muscle cells, and cardiomyocytes, in Human Protein Atlas single-cell database.

    RNA Sequencing:

    Article Title: Inhibition of RACK1-Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome.
    Article Snippet: To figure out the expression profile of the NLRP3 inflammasome in ARDS, we commenced by analyzing single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) of thirteen ARDS patients and six healthy donors, as reported by Sawitzki et al. [24] The Human Protein Atlas single-cell database showed that NLRP3 was primarily expressed in myeloid cells (Figure S2A, Supporting Information).

    Article Title: Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure
    Article Snippet: The distribution of Kmt5a transcript expression in cardiac tissue, categorized into fibroblasts, endothelial cells, smooth muscle cells, and cardiomyocytes, in Human Protein Atlas single-cell database.



    Similar Products

    human protein atlas single-cell database  (Human Protein Atlas)
    90
    Human Protein Atlas human protein atlas single-cell database
    Human Protein Atlas Single Cell Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+protein+atlas+single-cell+database/human+protein+atlas+cell+atlas+database/pm40349158-56-45-42
    Average 90 stars, based on 1 article reviews
    human protein atlas single-cell database - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    single-cell sequencing data from the human protein atlas (hpa) database  (Human Protein Atlas)
    90
    Human Protein Atlas single-cell sequencing data from the human protein atlas (hpa) database
    Disrupting Tug1 in <t>mouse</t> <t>prostate</t> luminal cells inhibits age-related glandular enlargement. a Analysis of Tug1 expression across various mouse tissues and its abundance in BPH tissues. The primary figure is derived from RT-qPCR analysis of Tug1 expression across various mouse tissues, with the top right figure showing Tug1 abundance using RNA-seq data from BPH tissues. b Examination of TUG1 expression in different cellular populations within human prostate tissues by using single-cell data from the <t>HPA</t> database. c A schematic representation of the anatomy of the mouse prostate. AP, anterior prostate; DLP, dorsolateral prostate; VP, ventral prostate. d RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the mouse prostate. e FISH combined with IF analysis for the localization and quantification of Tug1 in different regions of the mouse prostate. Scale bars: 50 μm. f Construction and characterization of the mouse model with prostate luminal cell-specific knockout of Tug1. The primary figure outlines the construction and analysis process for the mouse model, with the top right figure presenting RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the prostate in Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 12 months g Representative images of prostate tissues and H&E staining of the AP, DLP, and VP from Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. The dashed line area represents the prostate tissue of mice. Scale bars: 1 cm for gross; 50 μm for H&E staining. h-i Comparison of the relative expansion (h) or weight (i) of the AP, DLP, and VP of the mouse prostate between Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. * P < 0.05; ** P < 0.01; *** P < 0.001; n.s no significant.
    Single Cell Sequencing Data From The Human Protein Atlas (Hpa) Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+protein+atlas+single-cell+database/human+protein+atlas+cell+atlas+database/pmc11364272-85-8-5
    Average 90 stars, based on 1 article reviews
    single-cell sequencing data from the human protein atlas (hpa) database - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

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    Disrupting Tug1 in mouse prostate luminal cells inhibits age-related glandular enlargement. a Analysis of Tug1 expression across various mouse tissues and its abundance in BPH tissues. The primary figure is derived from RT-qPCR analysis of Tug1 expression across various mouse tissues, with the top right figure showing Tug1 abundance using RNA-seq data from BPH tissues. b Examination of TUG1 expression in different cellular populations within human prostate tissues by using single-cell data from the HPA database. c A schematic representation of the anatomy of the mouse prostate. AP, anterior prostate; DLP, dorsolateral prostate; VP, ventral prostate. d RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the mouse prostate. e FISH combined with IF analysis for the localization and quantification of Tug1 in different regions of the mouse prostate. Scale bars: 50 μm. f Construction and characterization of the mouse model with prostate luminal cell-specific knockout of Tug1. The primary figure outlines the construction and analysis process for the mouse model, with the top right figure presenting RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the prostate in Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 12 months g Representative images of prostate tissues and H&E staining of the AP, DLP, and VP from Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. The dashed line area represents the prostate tissue of mice. Scale bars: 1 cm for gross; 50 μm for H&E staining. h-i Comparison of the relative expansion (h) or weight (i) of the AP, DLP, and VP of the mouse prostate between Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. * P < 0.05; ** P < 0.01; *** P < 0.001; n.s no significant.

    Journal: Redox Biology

    Article Title: Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway

    doi: 10.1016/j.redox.2024.103298

    Figure Lengend Snippet: Disrupting Tug1 in mouse prostate luminal cells inhibits age-related glandular enlargement. a Analysis of Tug1 expression across various mouse tissues and its abundance in BPH tissues. The primary figure is derived from RT-qPCR analysis of Tug1 expression across various mouse tissues, with the top right figure showing Tug1 abundance using RNA-seq data from BPH tissues. b Examination of TUG1 expression in different cellular populations within human prostate tissues by using single-cell data from the HPA database. c A schematic representation of the anatomy of the mouse prostate. AP, anterior prostate; DLP, dorsolateral prostate; VP, ventral prostate. d RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the mouse prostate. e FISH combined with IF analysis for the localization and quantification of Tug1 in different regions of the mouse prostate. Scale bars: 50 μm. f Construction and characterization of the mouse model with prostate luminal cell-specific knockout of Tug1. The primary figure outlines the construction and analysis process for the mouse model, with the top right figure presenting RT-qPCR analysis of Tug1 expression in the AP, DLP, and VP of the prostate in Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 12 months g Representative images of prostate tissues and H&E staining of the AP, DLP, and VP from Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. The dashed line area represents the prostate tissue of mice. Scale bars: 1 cm for gross; 50 μm for H&E staining. h-i Comparison of the relative expansion (h) or weight (i) of the AP, DLP, and VP of the mouse prostate between Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice at 4, 8, and 12 months. * P < 0.05; ** P < 0.01; *** P < 0.001; n.s no significant.

    Article Snippet: Single-cell sequencing data from the Human Protein Atlas (HPA) database of prostate tissues revealed that IL-1β is primarily derived from macrophages ( d).

    Techniques: Expressing, Derivative Assay, Quantitative RT-PCR, RNA Sequencing, Knock-Out, Staining, Comparison

    Downregulation of AR promotes TUG1 expression via IL-1β/MYC signaling in prostate luminal cells. a-c Correlation analyses between TUG1 expression and AR mRNA levels (a), IL1B mRNA levels (b), and IL-1β protein concentrations (c) in BPH tissues from our validation cohort. d Analysis of IL1B expression across different cellular populations within human prostate tissues using single-cell data from the HPA database. e CISH combined with IHC staining for the quantification of TUG1, AR, CD68, and IL-1β in BPH tissues. f Schematic representation of the experimental approach for AR inhibitor treatment in Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice. g-h Analysis of DLP weight (g) and H&E staining (h) in the prostate of Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice treated with PBS or MDV3100. i IF staining for AR and CD68 in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. j RT-qPCR analysis of Il1b and Tug1 expression in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. k FISH combined with IF for the quantification of Tug1 and AR expression in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. l Integrative analysis of the JASPAR, PROMO, and AnimalTFDB databases along with TUG1-related genes to identify transcription factors involved in TUG1 regulation. m RT-qPCR analysis of Tug1 expression in RWPE-1 and BPH-1 cells transfected with siRNA targeting MYC or SP1, followed by treatment with PBS or IL-1β. n RT-qPCR analysis of TUG1 expression in RWPE-1 and BPH-1 cells treated with IL-1β and the MYC inhibitor 10058-F4. o IHC staining for MYC in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. p Identification of MYC binding motifs within the human TUG1 promoter region. q-r ChIP-qPCR analysis of the MYC binding site at the TUG1 promoter region in RWPE-1 (q) and BPH-1 (r) cells. s-t Luciferase reporter assays of wild-type (WT) and mutant (MUT) TUG1 promoters in RWPE-1 (s) and BPH-1 (t) cells transfected with MYC siRNA and treated with IL-1β. All scale bars: 50 μm * P < 0.05; ** P < 0.01; *** P < 0.001; n.s no significant.

    Journal: Redox Biology

    Article Title: Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway

    doi: 10.1016/j.redox.2024.103298

    Figure Lengend Snippet: Downregulation of AR promotes TUG1 expression via IL-1β/MYC signaling in prostate luminal cells. a-c Correlation analyses between TUG1 expression and AR mRNA levels (a), IL1B mRNA levels (b), and IL-1β protein concentrations (c) in BPH tissues from our validation cohort. d Analysis of IL1B expression across different cellular populations within human prostate tissues using single-cell data from the HPA database. e CISH combined with IHC staining for the quantification of TUG1, AR, CD68, and IL-1β in BPH tissues. f Schematic representation of the experimental approach for AR inhibitor treatment in Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice. g-h Analysis of DLP weight (g) and H&E staining (h) in the prostate of Pbsn-Cre4 Tug1 wt/wt or Pbsn-Cre4 Tug1 fl/fl mice treated with PBS or MDV3100. i IF staining for AR and CD68 in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. j RT-qPCR analysis of Il1b and Tug1 expression in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. k FISH combined with IF for the quantification of Tug1 and AR expression in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. l Integrative analysis of the JASPAR, PROMO, and AnimalTFDB databases along with TUG1-related genes to identify transcription factors involved in TUG1 regulation. m RT-qPCR analysis of Tug1 expression in RWPE-1 and BPH-1 cells transfected with siRNA targeting MYC or SP1, followed by treatment with PBS or IL-1β. n RT-qPCR analysis of TUG1 expression in RWPE-1 and BPH-1 cells treated with IL-1β and the MYC inhibitor 10058-F4. o IHC staining for MYC in the prostate of Pbsn-Cre4 Tug1 wt/wt mice treated with PBS or MDV3100. p Identification of MYC binding motifs within the human TUG1 promoter region. q-r ChIP-qPCR analysis of the MYC binding site at the TUG1 promoter region in RWPE-1 (q) and BPH-1 (r) cells. s-t Luciferase reporter assays of wild-type (WT) and mutant (MUT) TUG1 promoters in RWPE-1 (s) and BPH-1 (t) cells transfected with MYC siRNA and treated with IL-1β. All scale bars: 50 μm * P < 0.05; ** P < 0.01; *** P < 0.001; n.s no significant.

    Article Snippet: Single-cell sequencing data from the Human Protein Atlas (HPA) database of prostate tissues revealed that IL-1β is primarily derived from macrophages ( d).

    Techniques: Expressing, Biomarker Discovery, Immunohistochemistry, Staining, Quantitative RT-PCR, Transfection, Binding Assay, ChIP-qPCR, Luciferase, Mutagenesis